Healthy life expectancy for 187 countries, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Publication Summary

Published in The Lancet, December 2012

Research objective

Health progress requires more than simply delaying death or increasing life expectancy at birth. The presence of non‐fatal disease and disability are also very important considerations.

Over the last six decades, advances in medicine and public health, improved living standards, rising levels of education, and declines in fertility have contributed to dramatic reductions in mortality in most regions of the world. With the accompanying trend of population aging, there is increased recognition of the need to prioritize health in the later years of life.

Healthy life expectancy, or HALE, is a measure of average population health summarizing both mortality and non‐fatal outcomes. HALE is used for comparisons of health across countries or for measuring change over time. These comparisons can shed light on key questions about how morbidity worsens or improves as mortality declines.

Analytical approach

HALE was calculated by extending the conventional life table that is used to translate a schedule of agespecific death rates into estimates of life expectancy at different ages. Information on the average level of health experienced over each age interval was incorporated into the life table.

Three sets of inputs from GBD 2010 were used, including age‐specific information on mortality rates and prevalence of 1,160 conditions resulting from specific diseases, by sex, country, and year, and disability weights associated with the set of 220 distinct health states relating to those sequelae.

Estimates of average levels of overall health were computed for each age‐sex group, adjusting for comorbidity using a Monte Carlo simulation approach to capture the many ways in which multiple prevalent morbidities may combine in a given individual. These estimates of average health were incorporated in the life table using the Sullivan method, yielding healthy life expectancy estimates for each population in the study.

Results were evaluated across country and over time, and changes were evaluated to estimate the relative contributions of changes in child mortality, adult mortality, and disability prevalence as drivers of overall change in population health between 1990 and 2010.

Research findings

Gains in healthy life expectancy over the last two decades have been made primarily through reductions in child and adult mortality rather than reductions in years lived with a disability.

In 2010, global HALE at birth was 58.3 years for males and 61.8 for females, compared to 54.4 and 57.8, respectively, in 1990. The difference between life expectancy and HALE was 9.2 years for males and 11.5 years for females. The study also found that females lose more healthy life to disability than males between the ages of 15 and 65.

While life expectancy at birth increased by 4.7 years for males and 5.1 years for females, HALE at birth increased only 3.9 years and 4.0 years, respectively. This indicates that, on average, the world’s population surrenders more years of healthy life to various disabilities today than 20 years ago. Overall the gap between the sexes in both life expectancy and HALE continues to widen, as gains have been higher for women in both life expectancy and HALE.

HALE overall has increased in 19 of 21 regions, with the two dramatic exceptions being southern sub‐ Saharan Africa, where adult mortality from HIV/AIDS has erased years of life expectancy, and the Caribbean, where the 2010 earthquake in Haiti produced exceptionally high mortality that resulted in one‐time massive reductions in life expectancy. Across countries, HALE at birth in 2010 for males ranged from 27.9 in Haiti to 68.8 in Japan, and HALE at birth for females ranged from 37.1 in Haiti to 71.7 in Japan.

Policy implications

Prevention campaigns have succeeded in a range of infectious diseases, but they have yet to make progress on a large scale for a larger number of diseases and injuries that have left people functionally impaired. The failure to make significant progress in reducing the overall health impact of these diseases and injuries over the last 20 years should be cause for alarm and action.

Target‐setting exercises for health, such as the Millennium Development Goals (MDGs), have focused on reducing mortality from causes such as HIV, tuberculosis, and malaria, with varying results. However, there have been minimal changes in the overall prevalence of disability because such campaigns have not yet addressed diseases and injuries that leave people functionally impaired. HALE will likely be a useful indicator that could inform discussions about global health goals and targets for the post‐MDG era.

Countries are facing a coming wave of financial and social costs from the rising number of people living with diseases and injuries. The net effect on healthcare costs depends on the balance of costs associated with conditions such as diabetes, musculoskeletal disorders, mental and behavioural disorders and other leading contributors to disability, versus the costs of medical care.

If all countries could achieve the low years‐lived‐with‐disability per capita rates seen in Japan, for example, substantial increases in healthy life expectancy would be realized. These improvements would likely be accompanied by reductions in the costs of managing diseases and injuries.

Citation:

Salomon JA, Wang H, Freeman MK, Vos T, Flaxman AD, Lopez AD, Murray CJL. Healthy life expectancy for 187 countries, 1990–2010: a systematic analysis for the Global Burden Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2144–2162.

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Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S*, Aboyans V*, Abraham J*, Ackerman I*, Aggarwal R*, Ahn SY*, Ali MK*, Alvarado M*, Anderson HR*, Anderson LM*, Andrews KG*, Atkinson C*, Baddour LM*, Bahalim AN*, Barker-Collo S*, Barrero LH*, Bartels DH*, Basáñez MG*, Baxter A*, Bell ML*, Benjamin EJ*, Bennett D*, Bernabé E*, Bhalla K*, Bhandari B*, Bikbov B*, Bin Abdulhak A*, Birbeck G*, Black JA*, Blencowe H*, Blore JD*, Blyth F*, Bolliger I*, Bonaventure A*, Boufous S*, Bourne R*, Boussinesq M*, Braithwaite T*, Brayne C*, Bridgett L*, Brooker S*, Brooks P*, Brugha TS*, Bryan-Hancock C*, Bucello C*, Buchbinder R*, Buckle G*, Budke CM*, Burch M*, Burney P*, Burstein R*, Calabria B*, Campbell B*, Canter CE*, Carabin H*, Carapetis J*, Carmona L*, Cella C*, Charlson F*, Chen H*, Cheng ATA*, Chou D*, Chugh SS*, Coffeng LE*, Colan SD*, Colquhoun S*, Colson KE*, Condon J*, Connor MD*, Cooper LT*, Corriere M*, Cortinovis M*, Courville de Vaccaro K*, Couser W*, Cowie BC*, Criqui MH*, Cross M*, Dabhadkar KC*, Dahiya M*, Dahodwala N*, Damsere-Derry J*, Danaei G*, Davis A*, De Leo D*, Degenhardt L*, Dellavalle R*, Delossantos A*, Denenberg J*, Derrett S*, Des Jarlais DC*, Dharmaratne SD*, Dherani M*, Diaz-Torne C*, Dolk H*, Dorsey ER*, Driscoll T*, Duber H*, Ebel B*, Edmond K*, Elbaz A*, Eltahir Ali S*, Erskine H*, Erwin PJ*, Espindola P*, Ewoigbokhan SE*, Farzadfar F*, Feigin V*, Felson DT*, Ferrari A*, Ferri CP*, Fèvre EM*, Finucane MM*, Flaxman S*, Flood L*, Foreman K*, Forouzanfar MH*, Fowkes FGR*, Franklin R*, Fransen M*, Freeman MK*, Gabbe BJ*, Gabriel SE*, Gakidou E*, Ganatra HA*, Garcia B*, Gaspari F*, Gillum RF*, Gmel G*, Gosselin R*, Grainger R*, Groeger J*, Guillemin F*, Gunnell D*, Gupta R*, Haagsma J*, Hagan H*, Halasa YA*, Hall W*, Haring D*, Haro JM*, Harrison JE*, Havmoeller R*, Hay RJ*, Higashi H*, Hill C*, Hoen B*, Hoffman H*, Hotez PJ*, Hoy D*, Huang JJ*, Ibeanusi SE*, Jacobsen KH*, James SL*, Jarvis D*, Jasrasaria R*, Jayaraman S*, Johns N*, Jonas JB*, Karthikeyan G*, Kassebaum N*, Kawakami N*, Keren A*, Khoo J-P*, King CH*, Knowlton LM*, Kobusingye O*, Koranteng A*, Krishnamurthi R*, Lalloo R*, Laslett LL*, Lathlean T*, Leasher JL*, Lee YY*, Leigh J*, Lim SS*, Limb E*, Lin JK*, Lipnick M*, Lipshultz SE*, Liu W*, Loane M*, Lockett Ohno S*, Lyons R*, Ma J*, Mabweijano J*, MacIntyre MF*, Malekzadeh R*, Mallinger L*, Manivannan S*, Marcenes W*, March L*, Margolis DJ*, Marks GB*, Marks R*, Matsumori A*, Matzopoulos R*, Mayosi BM*, McAnulty JH*, McDermott MM*, McGill N*, McGrath J*, Medina-Mora ME*, Meltzer M*, Mensah GA*, Merriman TR*, Meyer AC*, Miglioli V*, Miller M*, Miller TR*, Mitchell PB*, Mocumbi AO*, Moffitt TE*, Mokdad AA*, Monasta L*, Montico M*, Moradi-Lakeh M*, Moran A*, Morawska L*, Mori R*, Murdoch ME*, Mwaniki MK*, Naidoo K*, Nair MN*, Naldi L*, Narayan KMV*, Nelson PK*, Nelson RG*, Nevitt MC*, Newton CR*, Nolte S*, Norman P*, Norman R*, O’Donnell M*, O’Hanlon S*, Olives C*, Omer SB*, Ortblad K*, Osborne R*, Ozgediz D*, Page A*, Pahari B*, Pandian JD*, Rivero AP*, Patten SB*, Pearce N*, Perez Padilla R*, Perez-Ruiz F*, Perico N*, Pesudovs K*, Phillips D*, Phillips MR*, Pierce K*, Pion S*, Polanczyk GV*, Polinder S*, Pope III CA*, Popova S*, Porrini E*, Pourmalek F*, Prince M*, Pullan RL*, Ramaiah KD*, Ranganathan D*, Razavi H*, Regan M*, Rehm JT*, Rein DB*, Remuzzi G*, Richardson K*, Rivara FP*, Roberts T*, Robinson C*, Rodriguez De Leòn F*, Ronfani L*, Room R*, Rosenfeld LC*, Rushton L*, Sacco RL*, Saha S*, Sampson U*, Sanchez-Riera L*, Sanman E*, Schwebel DC*, Scott JG*, Segui-Gomez M*, Shahraz S*, Shepard DS*, Shin H*, Shivakoti R*, Singh D*, Singh GM*, Singh JA*, Singleton J*, Sleet DA*, Sliwa K*, Smith E*, Smith JL*, Stapelberg NJC*, Steer A*, Steiner T*, Stolk WA*, Stovner LJ*, Sudfeld C*, Syed S*, Tamburlini G*, Tavakkoli M*, Taylor HR*, Taylor JA*, Taylor WJ*, Thomas B*, Thomson WM*, Thurston GD*, Tleyjeh IM*, Tonelli M*, Towbin JA*, Truelsen T*, Tsilimbaris MK*, Ubeda C*, Undurraga EA*, van der Werf MJ*, van Os J*, Vavilala MS*, Venketasubramanian N*, Wang M*, Wang W*, Watt K*, Weatherall DJ*, Weinstock MA*, Weintraub R*, Weisskopf MG*, Weissman MM*, White RA*, Whiteford H*, Wiersma ST*, Wilkinson JD*, Williams HC*, Williams SRM*, Witt E*, Wolfe F*, Woolf AD*, Wulf S*, Yeh PH*, Zaidi AKM*, Zheng ZJ*, Zonies D*, Lopez AD†, Murray CJL†‡. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2163–2196.

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Lim SS‡, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H*, Amann M*, Anderson HR*, Andrews KG*, Aryee M*, Atkinson C*, Bacchus LJ*, Bahalim AN*, Balakrishnan K*, Balmes J*, Barker-Collo S*, Baxter A*, Bell ML*, Blore JD*, Blyth F*, Bonner C*, Borges G*, Bourne R*, Boussinesq M*, Brauer M*, Brooks P*, Bruce NG*, Brunekreef B*, Bryan-Hancock C*, Bucello C*, Buchbinder R*, Bull F*, Burnett RT*, Byers TE*, Calabria B*, Carapetis J*, Carnahan E*, Chafe Z*, Charlson F*, Chen H*, Chen JS*, Cheng ATA*, Child JC*, Cohen A*, Colson KE*, Cowie BC*, Darby S*, Darling S*, Davis A*, Degenhardt L*, Dentener* F, Des Jarlais DC*, Devries K*, Dherani M*, Ding EL*, Dorsey ER*, Driscoll T*, Edmond K*, Eltahir Ali S*, Engell RE*, Erwin PJ*, Fahimi S*, Falder G*, Farzadfar F*, Ferrari A*, Finucane MM*, Flaxman S*, Fowkes FGR*, Freedman G*, Freeman MK*, Gakidou E*, Ghosh S*, Giovannucci E*, Gmel G*, Graham K*, Grainger R*, Grant B*, Gunnell D*, Gutierrez HR*, Hall W*, Hoek HW*, Hogan A*, Hosgood III, HD*, Hoy D*, Hu H*, Hubbell BJ*, Hutchings SJ*, Ibeanusi SE*, Jacklyn GL*, Jasrasaria R*, Jonas JB*, Kan H*, Kanis JA*, Kassebaum N*, Kawakami N*, Khang YH*, Khatibzadeh S*, Khoo JP*, Kok C*, Laden F*, Lalloo R*, Lan Q*, Lathlean T*, Leasher JL*, Leigh J*, Li Y*, Lin JK*, Lipshultz SE*, London S*, Lozano R*, Lu Y*, Mak J*, Malekzadeh R*, Mallinger L*, Marcenes W*, March L*, Marks R*, Martin R*, McGale P*, McGrath J*, Mehta S*, Mensah GA*, Merriman TR*, Micha R*, Michaud C*, Mishra V*, Mohd Hanafiah K*, Mokdad AA*, Morawska L*, Mozaffarian D*, Murphy T*, Naghavi M*, Neal B*, Nelson PK*, Nolla JM*, Norman R*, Olives C*, Omer SB*, Orchard J*, Osborne R*, Ostro B*, Page A*, Pandey KD*, Parry CDH*, Passmore E*, Patra J*, Pearce N*, Pelizzari PM*, Petzold M*, Phillips MR*, Pope D*, Pope III, CA*, Powles J*, Rao M*, Razavi H*, Rehfuess EA*, Rehm JT*, Ritz B*, Rivara FP*, Roberts T*, Robinson C*, Rodriguez-Portales JA*, Romieu I*, Room R*, Rosenfeld LC*, Roy A*, Rushton L*, Salomon JA*, Sampson U*, Sanchez-Riera L*, Sanman E*, Sapkota A*, Seedat S*, Shi P*, Shield K*, Shivakoti R*, Singh GM*, Sleet DA*, Smith E*, Smith KR*, Stapelberg NJC*, Steenland K*, Stöckl H*, Stovner LJ*, Straif K*, Straney L*, Thurston GD*, Tran JH*, Van Dingenen R*, van Donkelaar A*, Veerman JL*, Vijayakumar L*, Weintraub R*, Weissman MM*, White RA*, Whiteford H*, Wiersma ST*, Wilkinson JD*, Williams HC*, Williams W*, Wilson N*, Woolf AD*, Yip P*, Zielinski JM*, Lopez AD†, Murray CJL†, Ezzati M.† A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2224–2260.

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Wang H*, Dwyer-Lindgren L, Lofgren KT, Rajaratnam JK, Marcus JR, Levin-Rector A, Levitz C, Lopez AD, Murray CJL. Age-specific and sex-specific mortality in 187 countries, 1970–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2071–2094.

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Murray CJL†‡, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S*, Aboyans V*, Abraham J*, Ackerman I*, Aggarwal R*, Ahn SY*, Ali MA*, Alvarado M*, Anderson HR*, Anderson LM*, Andrews KG*, Atkinson C*, Baddour LM*, Bahalim AD*, Barker-Collo S*, Barrero LH*, Bartels DH*, Basáñez M-G*, Baxter A*, Bell ML*, Benjamin EJ*, Bennett D*, Bernabé E*, Bhalla K*, Bhandari B*, Bikbov B*, Abdulhak AB*, Birbeck G*, Black JA*, Blencowe H*, Blore JD*, Blyth F*, Bolliger I*, Bonaventure A*, Boufous S*, Bourne R*, Boussinesq M*, Braithwaite T*, Brayne C*, Bridgett L*, Brooker S*, Brooks P*, Brugha TS*, Bryan-Hancock C*, Bucello C*, Buchbinder R*, Buckle G*, Budke CM*, Burch M*, Burney P*, Burstein R*, Calabria B*, Campbell B*, Canter CE*, Carabin H*, Carapetis J*, Carmona L*, Cella C*, Charlson F*, Chen H*, Tai-Ann Cheng A*, Chou D*, Chugh SS*, Coffeng LE*, Colan SD*, Colquhoun S*, Colson KE*, Condon J*, Connor MD*, Cooper LT*, Corriere M*, Cortinovis M*, Courville de Vaccaro K*, Couser W*, Cowie BC*, Criqui MH*, Cross M*, Dabhadkar KC*, Dahiya M*, Dahodwala N*, Damsere-Derry J*, Danaei G*, Davis A*, De Leo D*, Degenhardt L*, Dellavalle R*, Delossantos A*, Denenberg J*, Derrett S*, Des Jarlais DC*, Dharmaratne SD*, Dherani M*, Diaz-Torne C*, Dolk H*, Dorsey ER*, Driscoll T*, Duber H*, Ebel B*, Edmond K*, Elbaz A*, Eltahir Ali S*, Erskine H*, Erwin PJ*, Espindola P*, Ewoigbokhan SE*, Farzadfar F*, Feigin V*, Felson DT*, Ferrari A*, Ferri CP*, Fèvre EM*, Finucane MM*, Flaxman S*, Flood L*, Foreman K*, Forouzanfar MH*, Fowkes FGR*, Fransen M*, Freeman MK*, Gabbe BJ*, Gabriel SE*, Gakidou E*, Ganatra HA*, Garcia B*, Gaspari F*, Gillum RF*, Gmel G*, Gonzalez-Medina D*, Gosselin R*, Grainger R*, Grant B*, Groeger J*, Guillemin F*, David Gunnell*, Gupta R*, Haagsma J*, Hagan H*, Halasa YA*, Hall W*, Haring D*, Haro*, James E Harrison JM*, Havmoeller R*, Hay RJ*, Higashi H*, Hill C*, Hoen B*, Hoffman H*, Hotez PJ*, Hoy D*, Huang JJ*, Ibeanusi SE*, Jacobsen KH*, James SL*, Jarvis D*, Jasrasaria R*, Jayaraman S*, Johns N*, Jonas JB*, Karthikeyan G*, Kassebaum N*, Kawakami N*, Keren A*, Khoo J-P*, King CH*, Knowlton LM*, Kobusingye O*, Koranteng A*, Krishnamurthi R*, Laden F*, Lalloo R*, Laslett LL*, Lathlean T*, Lin JL*, Lipnick M*, Lipshultz SE*, Liu W*, Loane M*, Ohno SL*, Lyons R*, Mabweijano J*, MacIntyre MF*, Mekzadeh R*, Mallinger L*, Manivannan S*, Marcenes W*, March L*, Margolis DJ*, Marks GB*, Marks R*, Matsumori A*, Matzopoulos R*, Mayosi BM*, McAnulty JH*, McDermott MM*, McGill N*, McGrath J*, Medina-Mora ME*, Meltzer M*, Mensah GA*, Merriman TR*, Meyer A-C*, Miglioli V*, Miller*, Ted R Miller M*, Mitchell PB*, Mock C*, Mocumbi AO*, Moffitt TE*, Mokdad AA*, Monasta L*, Montico M*, Moradi-Lakeh M*, Moran A*, Morawska L*, Mori R*, Murdoch ME*, Mwaniki MK*, Naidoo K*, Nair MN*, Naldi L*, Narayan KMV*, Nelson PK*, Nelson RG*, Nevitt MC*, Newton CR*, Nolte S*, Norman P*, Norman R*, O’Donnell M*, O’Hanlon S*, Olives C*, Omer SB*, Ortblad K*, Osborne R*, Ozgediz D*, Page A*, Pahari B*, Pandian JD*, Panozo Rivero A*, Patten SB*, Pearce N*, Perez Padilla R*, Perez-Ruiz F*, Perico N*, Pesudovs K*, Phillips D*, Phillips MR*, Pierce K*, Pion S*, Polanczyk GV*, Polinder S*, Pope CA III*, Popova S*, Porrini E*, Pourmalek F*, Prince M*, Pullan RL*, Ramaiah KD*, Ranganathan D*, Razavi H*, Regan M*, Rehm JT*, Rein DB*, Remuzzi G*, Richardson K*, Rivara FP*, Roberts T*, Robinson C*, Rodriguez De Leòn F*, Ronfani L*, Room R*, Rosenfeld LC*, Rushton L*, Sacco RL*, Saha S*, Sampson U*, Sanchez-Riera L*, Sanman E*, Schwebel DC*, Scott JG*, Segui-Gomez M*, Shahraz S*, Shepard DS*, Shin H*, Shivakoti R*, Singh D*, Singh GM*, Singh JA*, Singleton J*, Sleet DA*, Sliwa K*, Smith E*, Smith JL*, Stapelberg NJC*, Steer A*, Steiner T*, Stolk WA*, Stovner LJ*, Sudfeld C*, Syed S*, Tamburlini G*, Tavakkoli M*, Taylor HR*, Taylor JA*, Taylor WJ*, Thomas B*, Thomson WM*, Thurston GD*, Tleyjeh IM*, Tonelli M*, Towbin JA*, Truelsen T*, Tsilimbaris MK*, Ubeda C*, Undurraga EA*, van der Werf MJ*, van Os J*, Vavilala MS*, Venketasubramanian N*, Wang M*, Wang W*, Watt K*, Weatherall DJ*, Weinstock MA*, Weintraub R*, Weisskopf* MG, Weissman MM*, White RA*, Whiteford H*, Wiebe N*, Wiersma ST*, Wilkinson JD*, Williams HC*, Williams SRM*, Witt E*, Wolfe F*, Woolf*AD, Wulf S*, Yeh P-H*, Zaidi AKM*, Zheng Z-J*, Zonies D*, Alan D Lopez† . Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2197–2223.

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Salomon JA†, Vos T, Hogan DR, Gagnon M, Naghavi M, Mokdad A, Begum N, Shah R, Karyana M, Kosen S, Farje MR, Moncada G, Dutta A, Sazawal S, Dyer A, Seiler J, Aboyans V*, Baker L*, Baxter A*, Benjamin EJ*, Bhalla K*, Bin Abdulhak A*, Blyth F*, Bourne R*, Braithwaite T*, Brooks P*, Brugha TS*, Bryan-Hancock C*, Buchbinder R*, Burney P*, Calabria B*, Chen H*, Chugh SS*, Cooley R*, Criqui MH*, Cross M*, Dabhadkar KC*, Dahodwala N*, Davis A*, Degenhardt L*, Díaz-Torné C*, Dorsey ER*, Driscoll T*, Edmond K*, Elbaz A*, Ezzati M*, Feigin V*, Ferri CP*, Flaxman AD*, Flood L*, Fransen M*, Fuse K*, Gabbe BJ*, Gillum RF*, Haagsma J*, Harrison JE*, Havmoeller R*, Hay RJ*, Hel-Baqui A*, Hoek HW*, Hoffman H*, Hogeland E*, Hoy D*, Jarvis D*, Karthikeyan G*, Knowlton LM*, Lathlean T*, Leasher JL*, Lim SS*, Lipshultz SE*, Lopez AD*, Lozano R*, Lyons R*, Malekzadeh R*, Marcenes W*, March L *, Margolis DJ*, McGill N*, McGrath J*, Mensah GA*, Meyer AC*, Michaud C*, Moran A*, Mori R*, Murdoch ME*, Naldi L*, Newton CR*, Norman R*, Omer SB*, Osborne R*, Pearce N*, Perez-Ruiz F*, Perico N*, Pesudovs K*, Phillips D*, Pourmalek F*, Prince M*, Rehm JT*, Remuzzi G*, Richardson K*, Room R*, Saha S*, Sampson U*, Sanchez-Riera L*, Segui-Gomez M*, Shahraz S*, Shibuya K*, Singh D*, Sliwa K*, Smith E*, Soerjomataram I*, Steiner T*, Stolk WA*, Stovner LJ*, Sudfeld C*, Taylor HR*, Tleyjeh IM*, van der Werf MJ*, Watson WL*, Weatherall DJ*, Weintraub R*, Weisskopf MG*, Whiteford H*, Wilkinson JD*, Woolf AD*, Zheng Z-J*, Murray CJL. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2129–2143.

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Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V*, Abraham J*, Adair T*, Aggarwal R*, Ahn SY*, Alvarado M*, Anderson HR*, Anderson LM*, Andrews KG*, Atkinson C*, Baddour LM*, Barker‐Collo* S, Bartelsn DH*, Bell M*, Benjamin EJ*, Bennett D*, Bhalla K*, Bikbov B*, Abdulhak AB*, Birbeck G*, Blyth F*, Bolliger I*, Boufous S*, Bucello C*, Burch M*, Burney P*, Carapetis J*, Chen H*, Chou D*, Chugh SS*, Coffeng LE*, Colan SD*, Colquhoun S*, Colson KE*, Condon J*, Connor MD*, Cooper LT*, Corriere M*, Cortinovis M*, Courville de Vaccaro *, Couser W*, Cowie BC*, Criqui MH*, Cross M*, Dabhadkar KC*, Dahodwala N*, De Leo D*, Degenhardt L*, Delossantos A*, Denenberg J*, Des Jarlais DC*, Dharmaratne SD*, Dorsey EJ*, Driscoll T*, Duber H*, Ebel B*, Erwin PJ*, Espindola P*, Ezzati M*, Feigin V*, Flaxman A*, Forouzanfar MH*, Fowkes FGR*, Franklin R*, Fransen M*, Freeman MK*, Gabriel SE*, Gakidou E*, Gaspari F*, Gillum RJ*, Gonzalez‐Medina D*, Halasa YA*, Haring D*, Harrison JE*, Havmoeller R*, Hay RJ*, Hoen B*, Hotez PJ*, Hoy D*, Jacobsen KH*, James SL*, Jasrasaria R*, Jayaraman S*, Johns N*, Karthikeyan G*, Kassebaum N*, Keren A*, Khoo J-P*, Knowlton LM*, Kobusingye O*, Koranteng A*, Krishnamurthi R*, Lipnick M*, Lipshultz SE*, Ohno SL*, Mabweijano J*, MacIntyre MF*, Mallinger L*, March L*, Marks GM*, Marks R*, Matsumori A*, Matzopoulos R*, Mayosi BM*, McAnulty JH*, McDermott MM*, McGrath J*, Mensah GA*, Merriman TR*, Michaud C*, Miller M*, Miller TR*, Mock C*, Mocumbi AO*, Mokdad AA*, Moran A*, Mulholland K*, Nair MN*, Naldi L*, Narayan KMV*, Nasseri K*, Norman P*, O’Donnell M*, Omer SB*, Ortblad K*, Osborne R*, Ozgediz D*, Pahari B*, Pandian JD*, Panozo Rivero A*, Perez Padilla R*, Perez‐Ruiz F*, Perico N*, Phillips D*, Pierce K*, Pope CA III*, Porrini E*, Pourmalek F*, Raju M*, Ranganathan D*, Rehm JT*, Rein DB*, Remuzzi G*, Rivara FP*, Roberts T*, Rodriguez De León F*, Rosenfeld LC*, Rushton L*, Sacco RL*, Salomon JA*, Sampson U*, Sanman E*, Schwebel DC*, Segui‐Gomez M*, Shepard DS*, Singh D*, Singleton J*, Sliwa K*, Smith D*, Steer A*, Taylor JA*, Thomas B*, Tleyjeh IM*, Towbin JA*, Truelsen T*, Undurraga EA*, Venketasubramanian N*, Vijayakumar L*, Vos T*, Wagner GR*, Wang M*, Wang W*, Watt K*, Weinstock MA*, Weintraub R*, Wilkinson JA*, Woolf AD*, Wulf S*, Yeh P-H*, Yip P*, Zabetian A*, Zheng J-J*, Lopez AD†, Murray CJL.†‡ Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2095–2128.

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