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Burden of Disease

Research Team

The Burden of Disease research team aims to provide comparable estimates of the impact of diseases and injuries in all countries to inform priorities for policies, funding, and further research. Individual indicators about health conditions – such as the total number of deaths by age and sex, or the incidence of particular conditions – are useful but insufficient to understand the real impact of a given condition on a population.

To assess the burden of disease, both mortality and morbidity must be taken into account using the disability-adjusted life year (DALY). The DALY is a time-based measure that combines years of life lost due to premature mortality and years of life lost due to time lived in health states of less than ideal health.
 
Several research activities conducted by this team feed into the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010).
 
Other key activities for the Burden of Disease research team include data collection and the generation of incidence and prevalence estimates for key conditions. 

 

Key Activities

  • Refine methods to assess incidence and prevalence of key conditions in populations
Population-level incidence and prevalence of chronic conditions are often poorly understood because of a lack of data. A validated population-based survey providing accurate information on such conditions could be a cost-effective way to fill significant data gaps. As part of the Population Health Metrics Research Consortium Mexico Study, the research team has fielded a survey instrument in Mexico City.
 
To validate the instrument, the study ties the surveys back to verified clinical information about individuals interviewed about conditions of interest, including angina pectoris, chronic obstructive pulmonary disease, asthma, depression, vision loss, hearing loss, cirrhosis of the liver, osteoarthritis, rheumatoid arthritis, and cataracts.
 

Drawing from the lessons learned through the analysis of verbal autopsies, the research team is developing a new method, the Symptom Diagnosis Method, to analyze the collected data.

  • Collaborate with the Ministry of Health for the Kingdom of Saudi Arabia to assess that country’s national burden of disease

IHME is engaging with the Ministry of Health for the Kingdom of Saudia Arabia to develop a multi-source health information system that will allow policymakers the ability to track the burden of disease and coverage of key interventions at the national and subnational level.  This project is beginning with an assessment of existing sources of data, including vital registration, administrative records, surveys, and hospital records.  IHME and the MoH are together designing new survey instruments to complement existing data sources and hope to pilot their use in the coming year.

  • Formulate analytic strategies and begin data collation and review for select subnational burden studies

We expect that the publication of the GBD regional results will help to spawn interest in national and subnational estimates for multiple countries. Achieving the most highly accurate and complete results for multiple countries at the subnational level will require additional analytic adaptation, more subnational data on key conditions and risk factors, and the generation of key estimates of covariates at the subnational level. IHME currently is party to a memorandum of understanding with the University of Queensland and the China Centers for Disease Control in which the University of Queensland and IHME agree to provide training for GBD methods. Discussions have progressed about the possibility of augmenting that collaborative agenda with national and subnational burden estimates.

The ministries of health in Brazil and Zambia have also expressed initial interest in related research. IHME will explore the scale, scope, and parameters of these potential endeavors in FY13, and if successful in forging collaborative agreements and identifying resources, will proceed with implementation as appropriate.

  • Pending funding, begin the process of routinely updating burden estimates for 291 conditions

We believe that policymakers, donors, and researchers would benefit from and desire a more continuous effort to comprehensively update burden estimates. Historical efforts have been inconsistent and spread out over long periods of time. Even the most current GBD study has taken over five years to complete. IHME believes that with increased resources the analytic tools that have been developed could be further improved to be faster and leaner computationally. If a team could be supported to then continuously update the data available from the epidemiological literature, hospital data, disease registries, vital registration, and surveys, then in concert there could be updates to modeling exercises and computation of estimates on a much quicker timeline than past efforts.

IHME has formulated a proposal in this regard and will aim to find funding for this purpose in FY13. If funding can be obtained, this activity could have a significant impact upon the expansion of evidence for health-related policymaking and funding and could also represent an important step forward in capitalizing upon the gains realized in the past several years in methodological development and computational capacity for burden estimation. 

Impact

Improving the health and well-being of the world’s population is a moral imperative and is essential for global stability and progress. The vast energies, technologies, and resources pouring into global health have given us the capacity to reduce disease, improve health conditions, and address deep inequalities in health between populations.

The Burden of Disease research team provides tools and knowledge to inform efforts for making effective interventions possible.

Related Publications & Presentations

Research Articles Policy Reports

Salomon JA, Wang H, Freeman MK, Vos T, Flaxman AD, Lopez AD, Murray CJL. Healthy life expectancy for 187 countries, 1990–2010: a systematic analysis for the Global Burden Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2144–2162.

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Wang H*, Dwyer-Lindgren L, Lofgren KT, Rajaratnam JK, Marcus JR, Levin-Rector A, Levitz C, Lopez AD, Murray CJL. Age-specific and sex-specific mortality in 187 countries, 1970–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2071–2094.

*Corresponding author

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Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S*, Aboyans V*, Abraham J*, Ackerman I*, Aggarwal R*, Ahn SY*, Ali MK*, Alvarado M*, Anderson HR*, Anderson LM*, Andrews KG*, Atkinson C*, Baddour LM*, Bahalim AN*, Barker-Collo S*, Barrero LH*, Bartels DH*, Basáñez MG*, Baxter A*, Bell ML*, Benjamin EJ*, Bennett D*, Bernabé E*, Bhalla K*, Bhandari B*, Bikbov B*, Bin Abdulhak A*, Birbeck G*, Black JA*, Blencowe H*, Blore JD*, Blyth F*, Bolliger I*, Bonaventure A*, Boufous S*, Bourne R*, Boussinesq M*, Braithwaite T*, Brayne C*, Bridgett L*, Brooker S*, Brooks P*, Brugha TS*, Bryan-Hancock C*, Bucello C*, Buchbinder R*, Buckle G*, Budke CM*, Burch M*, Burney P*, Burstein R*, Calabria B*, Campbell B*, Canter CE*, Carabin H*, Carapetis J*, Carmona L*, Cella C*, Charlson F*, Chen H*, Cheng ATA*, Chou D*, Chugh SS*, Coffeng LE*, Colan SD*, Colquhoun S*, Colson KE*, Condon J*, Connor MD*, Cooper LT*, Corriere M*, Cortinovis M*, Courville de Vaccaro K*, Couser W*, Cowie BC*, Criqui MH*, Cross M*, Dabhadkar KC*, Dahiya M*, Dahodwala N*, Damsere-Derry J*, Danaei G*, Davis A*, De Leo D*, Degenhardt L*, Dellavalle R*, Delossantos A*, Denenberg J*, Derrett S*, Des Jarlais DC*, Dharmaratne SD*, Dherani M*, Diaz-Torne C*, Dolk H*, Dorsey ER*, Driscoll T*, Duber H*, Ebel B*, Edmond K*, Elbaz A*, Eltahir Ali S*, Erskine H*, Erwin PJ*, Espindola P*, Ewoigbokhan SE*, Farzadfar F*, Feigin V*, Felson DT*, Ferrari A*, Ferri CP*, Fèvre EM*, Finucane MM*, Flaxman S*, Flood L*, Foreman K*, Forouzanfar MH*, Fowkes FGR*, Franklin R*, Fransen M*, Freeman MK*, Gabbe BJ*, Gabriel SE*, Gakidou E*, Ganatra HA*, Garcia B*, Gaspari F*, Gillum RF*, Gmel G*, Gosselin R*, Grainger R*, Groeger J*, Guillemin F*, Gunnell D*, Gupta R*, Haagsma J*, Hagan H*, Halasa YA*, Hall W*, Haring D*, Haro JM*, Harrison JE*, Havmoeller R*, Hay RJ*, Higashi H*, Hill C*, Hoen B*, Hoffman H*, Hotez PJ*, Hoy D*, Huang JJ*, Ibeanusi SE*, Jacobsen KH*, James SL*, Jarvis D*, Jasrasaria R*, Jayaraman S*, Johns N*, Jonas JB*, Karthikeyan G*, Kassebaum N*, Kawakami N*, Keren A*, Khoo J-P*, King CH*, Knowlton LM*, Kobusingye O*, Koranteng A*, Krishnamurthi R*, Lalloo R*, Laslett LL*, Lathlean T*, Leasher JL*, Lee YY*, Leigh J*, Lim SS*, Limb E*, Lin JK*, Lipnick M*, Lipshultz SE*, Liu W*, Loane M*, Lockett Ohno S*, Lyons R*, Ma J*, Mabweijano J*, MacIntyre MF*, Malekzadeh R*, Mallinger L*, Manivannan S*, Marcenes W*, March L*, Margolis DJ*, Marks GB*, Marks R*, Matsumori A*, Matzopoulos R*, Mayosi BM*, McAnulty JH*, McDermott MM*, McGill N*, McGrath J*, Medina-Mora ME*, Meltzer M*, Mensah GA*, Merriman TR*, Meyer AC*, Miglioli V*, Miller M*, Miller TR*, Mitchell PB*, Mocumbi AO*, Moffitt TE*, Mokdad AA*, Monasta L*, Montico M*, Moradi-Lakeh M*, Moran A*, Morawska L*, Mori R*, Murdoch ME*, Mwaniki MK*, Naidoo K*, Nair MN*, Naldi L*, Narayan KMV*, Nelson PK*, Nelson RG*, Nevitt MC*, Newton CR*, Nolte S*, Norman P*, Norman R*, O’Donnell M*, O’Hanlon S*, Olives C*, Omer SB*, Ortblad K*, Osborne R*, Ozgediz D*, Page A*, Pahari B*, Pandian JD*, Rivero AP*, Patten SB*, Pearce N*, Perez Padilla R*, Perez-Ruiz F*, Perico N*, Pesudovs K*, Phillips D*, Phillips MR*, Pierce K*, Pion S*, Polanczyk GV*, Polinder S*, Pope III CA*, Popova S*, Porrini E*, Pourmalek F*, Prince M*, Pullan RL*, Ramaiah KD*, Ranganathan D*, Razavi H*, Regan M*, Rehm JT*, Rein DB*, Remuzzi G*, Richardson K*, Rivara FP*, Roberts T*, Robinson C*, Rodriguez De Leòn F*, Ronfani L*, Room R*, Rosenfeld LC*, Rushton L*, Sacco RL*, Saha S*, Sampson U*, Sanchez-Riera L*, Sanman E*, Schwebel DC*, Scott JG*, Segui-Gomez M*, Shahraz S*, Shepard DS*, Shin H*, Shivakoti R*, Singh D*, Singh GM*, Singh JA*, Singleton J*, Sleet DA*, Sliwa K*, Smith E*, Smith JL*, Stapelberg NJC*, Steer A*, Steiner T*, Stolk WA*, Stovner LJ*, Sudfeld C*, Syed S*, Tamburlini G*, Tavakkoli M*, Taylor HR*, Taylor JA*, Taylor WJ*, Thomas B*, Thomson WM*, Thurston GD*, Tleyjeh IM*,  Tonelli M*, Towbin JA*, Truelsen T*, Tsilimbaris MK*, Ubeda C*, Undurraga EA*, van der Werf MJ*, van Os J*, Vavilala MS*, Venketasubramanian N*, Wang M*, Wang W*, Watt K*, Weatherall DJ*, Weinstock MA*, Weintraub R*, Weisskopf MG*, Weissman MM*, White RA*, Whiteford H*, Wiersma ST*, Wilkinson JD*, Williams HC*, Williams SRM*, Witt E*, Wolfe F*, Woolf AD*, Wulf S*, Yeh PH*, Zaidi AKM*, Zheng ZJ*, Zonies D*, Lopez AD†, Murray CJL†‡. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2163–2196.

* Authors listed alphabetically
† Joint senior authors
‡ Corresponding author
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Lim SS‡, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H*, Amann M*, Anderson HR*, Andrews KG*, Aryee M*, Atkinson C*, Bacchus LJ*, Bahalim AN*, Balakrishnan K*, Balmes J*, Barker-Collo S*, Baxter A*, Bell ML*, Blore JD*, Blyth F*, Bonner C*, Borges G*, Bourne R*, Boussinesq M*, Brauer M*, Brooks P*, Bruce NG*, Brunekreef B*, Bryan-Hancock C*, Bucello C*, Buchbinder R*, Bull F*, Burnett RT*, Byers TE*, Calabria B*, Carapetis J*, Carnahan E*, Chafe Z*, Charlson F*, Chen H*, Chen JS*, Cheng ATA*, Child JC*, Cohen A*, Colson KE*, Cowie BC*, Darby S*, Darling S*, Davis A*, Degenhardt L*, Dentener* F, Des Jarlais DC*, Devries K*, Dherani M*, Ding EL*, Dorsey ER*, Driscoll T*, Edmond K*, Eltahir Ali S*, Engell RE*, Erwin PJ*, Fahimi S*, Falder G*, Farzadfar F*, Ferrari A*, Finucane MM*, Flaxman S*, Fowkes FGR*, Freedman G*, Freeman MK*, Gakidou E*, Ghosh S*, Giovannucci E*, Gmel G*, Graham K*, Grainger R*, Grant B*, Gunnell D*, Gutierrez HR*, Hall W*, Hoek HW*, Hogan A*, Hosgood III, HD*, Hoy D*, Hu H*, Hubbell BJ*, Hutchings SJ*, Ibeanusi SE*, Jacklyn GL*, Jasrasaria R*, Jonas JB*, Kan H*, Kanis JA*, Kassebaum N*, Kawakami N*, Khang YH*, Khatibzadeh S*, Khoo JP*, Kok C*, Laden F*, Lalloo R*, Lan Q*, Lathlean T*, Leasher JL*, Leigh J*, Li Y*, Lin JK*, Lipshultz SE*, London S*, Lozano R*, Lu Y*, Mak J*, Malekzadeh R*, Mallinger L*, Marcenes W*, March L*, Marks R*, Martin R*, McGale P*, McGrath J*, Mehta S*, Mensah GA*, Merriman TR*, Micha R*, Michaud C*, Mishra V*, Mohd Hanafiah K*, Mokdad AA*, Morawska L*, Mozaffarian D*, Murphy T*, Naghavi M*, Neal B*, Nelson PK*, Nolla JM*, Norman R*, Olives C*, Omer SB*, Orchard J*, Osborne R*, Ostro B*, Page A*, Pandey KD*, Parry CDH*, Passmore E*, Patra J*, Pearce N*, Pelizzari PM*, Petzold M*, Phillips MR*, Pope D*, Pope III, CA*, Powles J*, Rao M*, Razavi H*, Rehfuess EA*, Rehm JT*, Ritz B*, Rivara FP*, Roberts T*, Robinson C*, Rodriguez-Portales JA*, Romieu I*, Room R*, Rosenfeld LC*, Roy A*, Rushton L*, Salomon JA*, Sampson U*, Sanchez-Riera L*, Sanman E*, Sapkota A*, Seedat S*, Shi P*, Shield K*, Shivakoti R*, Singh GM*, Sleet DA*, Smith E*, Smith KR*, Stapelberg NJC*, Steenland K*, Stöckl H*, Stovner LJ*, Straif K*, Straney L*, Thurston GD*, Tran JH*, Van Dingenen R*, van Donkelaar A*, Veerman JL*, Vijayakumar L*, Weintraub R*, Weissman MM*, White RA*, Whiteford H*, Wiersma ST*, Wilkinson JD*, Williams HC*, Williams W*, Wilson N*, Woolf AD*, Yip P*, Zielinski JM*, Lopez AD†, Murray CJL†, Ezzati M.† A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2224–2260.

* Authors listed alphabetically
† Joint senior authors
‡ Corresponding author
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Salomon JA†, Vos T, Hogan DR, Gagnon M, Naghavi M, Mokdad A, Begum N, Shah R, Karyana M, Kosen S, Farje MR, Moncada G, Dutta A, Sazawal S, Dyer A, Seiler J,  Aboyans V*, Baker L*, Baxter A*, Benjamin EJ*, Bhalla K*, Bin Abdulhak A*, Blyth F*, Bourne R*, Braithwaite T*, Brooks P*, Brugha TS*, Bryan-Hancock C*, Buchbinder R*, Burney P*, Calabria B*, Chen H*, Chugh SS*, Cooley R*, Criqui MH*, Cross M*, Dabhadkar KC*, Dahodwala N*, Davis A*, Degenhardt L*, Díaz-Torné C*, Dorsey ER*, Driscoll T*, Edmond K*, Elbaz A*, Ezzati M*, Feigin V*, Ferri CP*, Flaxman AD*, Flood L*, Fransen M*, Fuse K*, Gabbe BJ*, Gillum RF*, Haagsma J*, Harrison JE*, Havmoeller R*, Hay RJ*, Hel-Baqui A*, Hoek HW*, Hoffman H*, Hogeland E*, Hoy D*, Jarvis D*, Karthikeyan G*, Knowlton LM*, Lathlean T*, Leasher JL*, Lim SS*, Lipshultz SE*, Lopez AD*,  Lozano R*, Lyons R*, Malekzadeh R*, Marcenes W*, March L *, Margolis DJ*, McGill N*, McGrath J*, Mensah GA*, Meyer AC*, Michaud C*,  Moran A*, Mori R*, Murdoch ME*, Naldi L*, Newton CR*, Norman R*, Omer SB*, Osborne R*, Pearce N*, Perez-Ruiz F*, Perico N*, Pesudovs K*, Phillips D*, Pourmalek F*, Prince M*, Rehm JT*, Remuzzi G*, Richardson K*, Room R*, Saha S*, Sampson U*, Sanchez-Riera L*, Segui-Gomez M*, Shahraz S*, Shibuya K*, Singh D*,  Sliwa K*, Smith E*, Soerjomataram I*, Steiner T*, Stolk WA*, Stovner LJ*, Sudfeld C*, Taylor HR*, Tleyjeh IM*, van der Werf MJ*, Watson WL*, Weatherall DJ*, Weintraub R*, Weisskopf MG*, Whiteford H*, Wilkinson JD*, Woolf AD*, Zheng Z-J*, Murray CJL. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2129–2143.

*Authors listed alphabetically
†Corresponding author
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Murray CJL†‡, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S*, Aboyans V*, Abraham J*, Ackerman I*, Aggarwal R*, Ahn SY*, Ali MA*, Alvarado M*, Anderson HR*, Anderson LM*, Andrews KG*, Atkinson C*, Baddour LM*, Bahalim AD*, Barker-Collo S*, Barrero LH*, Bartels DH*, Basáñez M-G*, Baxter A*, Bell ML*, Benjamin EJ*, Bennett D*, Bernabé E*, Bhalla K*, Bhandari B*, Bikbov B*, Abdulhak AB*, Birbeck G*, Black JA*, Blencowe H*, Blore JD*, Blyth F*, Bolliger I*, Bonaventure A*, Boufous S*, Bourne R*, Boussinesq M*, Braithwaite T*, Brayne C*, Bridgett L*, Brooker S*, Brooks P*, Brugha TS*, Bryan-Hancock C*, Bucello C*, Buchbinder R*, Buckle G*, Budke CM*, Burch M*, Burney P*, Burstein R*, Calabria B*, Campbell B*, Canter CE*, Carabin H*, Carapetis J*, Carmona L*, Cella C*, Charlson F*, Chen H*, Tai-Ann Cheng A*, Chou D*, Chugh SS*, Coffeng LE*, Colan SD*, Colquhoun S*, Colson KE*, Condon J*, Connor MD*, Cooper LT*, Corriere M*, Cortinovis M*, Courville de Vaccaro K*, Couser W*, Cowie BC*, Criqui MH*, Cross M*, Dabhadkar KC*, Dahiya M*, Dahodwala N*, Damsere-Derry J*, Danaei G*, Davis A*, De Leo D*, Degenhardt L*, Dellavalle R*, Delossantos A*, Denenberg J*, Derrett S*, Des Jarlais DC*, Dharmaratne SD*, Dherani M*, Diaz-Torne C*, Dolk H*, Dorsey ER*, Driscoll T*, Duber H*, Ebel B*, Edmond K*, Elbaz A*, Eltahir Ali S*, Erskine H*, Erwin PJ*, Espindola P*, Ewoigbokhan SE*, Farzadfar F*, Feigin V*, Felson DT*, Ferrari A*, Ferri CP*, Fèvre EM*, Finucane MM*, Flaxman S*, Flood L*, Foreman K*, Forouzanfar MH*, Fowkes FGR*, Fransen M*, Freeman MK*, Gabbe BJ*, Gabriel SE*, Gakidou E*, Ganatra HA*, Garcia B*, Gaspari F*, Gillum RF*, Gmel G*, Gonzalez-Medina D*, Gosselin R*, Grainger R*, Grant B*, Groeger J*, Guillemin F*, David Gunnell*, Gupta R*, Haagsma J*, Hagan H*, Halasa YA*, Hall W*, Haring D*, Haro*, James E Harrison JM*, Havmoeller R*, Hay RJ*, Higashi H*, Hill C*, Hoen B*, Hoffman H*, Hotez PJ*, Hoy D*, Huang JJ*, Ibeanusi SE*, Jacobsen KH*, James SL*, Jarvis D*, Jasrasaria R*, Jayaraman S*, Johns N*, Jonas JB*, Karthikeyan G*, Kassebaum N*, Kawakami N*, Keren A*, Khoo J-P*, King CH*, Knowlton LM*, Kobusingye O*, Koranteng A*, Krishnamurthi R*, Laden F*, Lalloo R*, Laslett LL*, Lathlean T*, Lin JL*, Lipnick M*, Lipshultz SE*, Liu W*, Loane M*, Ohno SL*, Lyons R*, Mabweijano J*, MacIntyre MF*, Mekzadeh R*, Mallinger L*, Manivannan S*, Marcenes W*, March L*, Margolis DJ*, Marks GB*, Marks R*, Matsumori A*, Matzopoulos R*, Mayosi BM*, McAnulty JH*, McDermott MM*, McGill N*, McGrath J*, Medina-Mora ME*, Meltzer M*, Mensah GA*, Merriman TR*, Meyer A-C*, Miglioli V*, Miller*, Ted R Miller M*, Mitchell PB*, Mock C*, Mocumbi AO*, Moffitt TE*, Mokdad AA*, Monasta L*, Montico M*, Moradi-Lakeh M*, Moran A*, Morawska L*, Mori R*, Murdoch ME*, Mwaniki MK*, Naidoo K*, Nair MN*, Naldi L*, Narayan KMV*, Nelson PK*, Nelson RG*, Nevitt MC*, Newton CR*, Nolte S*, Norman P*, Norman R*, O’Donnell M*, O’Hanlon S*, Olives C*, Omer SB*, Ortblad K*, Osborne R*, Ozgediz D*, Page A*, Pahari B*, Pandian JD*,  Panozo Rivero A*, Patten SB*, Pearce N*, Perez Padilla R*, Perez-Ruiz F*, Perico N*, Pesudovs K*, Phillips D*, Phillips MR*, Pierce K*, Pion S*, Polanczyk GV*, Polinder S*, Pope CA III*, Popova S*, Porrini E*, Pourmalek F*, Prince M*, Pullan RL*, Ramaiah KD*, Ranganathan D*, Razavi H*, Regan M*, Rehm JT*, Rein DB*, Remuzzi G*, Richardson K*, Rivara FP*, Roberts T*, Robinson C*, Rodriguez De Leòn F*, Ronfani L*, Room R*, Rosenfeld LC*, Rushton L*, Sacco RL*, Saha S*, Sampson U*, Sanchez-Riera L*, Sanman E*, Schwebel DC*, Scott JG*, Segui-Gomez M*, Shahraz S*, Shepard DS*, Shin H*, Shivakoti R*, Singh D*, Singh GM*, Singh JA*, Singleton J*, Sleet DA*, Sliwa K*, Smith E*, Smith JL*, Stapelberg NJC*, Steer A*, Steiner T*, Stolk WA*, Stovner LJ*, Sudfeld C*, Syed S*, Tamburlini G*, Tavakkoli M*, Taylor HR*, Taylor JA*, Taylor WJ*, Thomas B*, Thomson WM*, Thurston GD*, Tleyjeh IM*, Tonelli M*, Towbin JA*, Truelsen T*, Tsilimbaris MK*, Ubeda C*, Undurraga EA*, van der Werf MJ*, van Os J*, Vavilala MS*, Venketasubramanian N*, Wang M*, Wang W*, Watt K*, Weatherall DJ*, Weinstock MA*, Weintraub R*, Weisskopf* MG, Weissman MM*, White RA*, Whiteford H*, Wiebe N*, Wiersma ST*, Wilkinson JD*, Williams HC*, Williams SRM*, Witt E*, Wolfe F*, Woolf*AD, Wulf S*, Yeh P-H*, Zaidi AKM*, Zheng Z-J*, Zonies D*, Alan D Lopez† . Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2197–2223.

* Authors listed alphabetically
† Joint senior authors
‡ Corresponding author
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Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V*, Abraham J*, Adair T*, Aggarwal R*, Ahn SY*, Alvarado M*, Anderson HR*, Anderson LM*, Andrews KG*, Atkinson C*, Baddour LM*, Barker‐Collo* S, Bartelsn DH*, Bell M*, Benjamin EJ*, Bennett D*, Bhalla K*, Bikbov B*, Abdulhak AB*, Birbeck G*, Blyth F*, Bolliger I*, Boufous S*, Bucello C*, Burch M*, Burney P*, Carapetis J*, Chen H*, Chou D*, Chugh SS*, Coffeng LE*, Colan SD*, Colquhoun S*, Colson KE*, Condon J*, Connor MD*, Cooper LT*, Corriere M*, Cortinovis M*, Courville de Vaccaro *, Couser W*, Cowie BC*, Criqui MH*, Cross M*, Dabhadkar KC*, Dahodwala N*, De Leo D*, Degenhardt L*, Delossantos A*, Denenberg J*, Des Jarlais DC*, Dharmaratne SD*, Dorsey EJ*, Driscoll T*, Duber H*, Ebel B*, Erwin PJ*, Espindola P*, Ezzati M*, Feigin V*, Flaxman A*, Forouzanfar MH*, Fowkes FGR*, Franklin R*, Fransen M*, Freeman MK*, Gabriel SE*, Gakidou E*, Gaspari F*, Gillum RJ*, Gonzalez‐Medina D*, Halasa YA*, Haring D*, Harrison JE*, Havmoeller R*, Hay RJ*, Hoen B*, Hotez PJ*, Hoy D*, Jacobsen KH*, James SL*, Jasrasaria R*, Jayaraman S*,  Johns N*, Karthikeyan G*, Kassebaum N*, Keren A*, Khoo J-P*, Knowlton LM*, Kobusingye O*, Koranteng A*, Krishnamurthi R*, Lipnick M*, Lipshultz SE*, Ohno SL*, Mabweijano J*, MacIntyre MF*, Mallinger L*, March L*, Marks GM*, Marks R*, Matsumori A*, Matzopoulos R*, Mayosi BM*, McAnulty JH*, McDermott MM*, McGrath J*, Mensah GA*, Merriman TR*, Michaud C*, Miller M*, Miller TR*, Mock C*, Mocumbi AO*, Mokdad AA*, Moran A*, Mulholland K*, Nair MN*, Naldi L*, Narayan KMV*, Nasseri K*, Norman P*, O’Donnell M*, Omer SB*, Ortblad K*, Osborne R*, Ozgediz D*, Pahari B*, Pandian JD*, Panozo Rivero A*, Perez Padilla R*, Perez‐Ruiz F*, Perico N*, Phillips D*, Pierce K*,  Pope CA III*, Porrini E*, Pourmalek F*, Raju M*, Ranganathan D*, Rehm JT*, Rein DB*, Remuzzi G*, Rivara FP*, Roberts T*, Rodriguez De León F*, Rosenfeld LC*, Rushton L*, Sacco RL*, Salomon JA*, Sampson U*, Sanman E*, Schwebel DC*, Segui‐Gomez M*, Shepard DS*, Singh D*, Singleton J*, Sliwa K*, Smith D*, Steer A*, Taylor JA*, Thomas B*, Tleyjeh IM*, Towbin JA*, Truelsen T*, Undurraga EA*, Venketasubramanian N*, Vijayakumar L*, Vos T*, Wagner GR*, Wang M*, Wang W*, Watt K*, Weinstock MA*, Weintraub R*, Wilkinson JA*, Woolf AD*, Wulf S*, Yeh P-H*, Yip P*, Zabetian A*, Zheng J-J*, Lopez AD†, Murray CJL.†‡ Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2095–2128. 

* Authors listed alphabetically
† Joint senior authors
‡ Corresponding author
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Lozano R, Wang H, Foreman KJ, Rajaratnam JK, Naghavi M, Marcus JR, Dwyer-Lindgren L, Lofgren KT, Phillips D, Atkinson C, Lopez AD, Murray CJL. Progress towards Millennium Development Goals 4 and 5 on maternal and child mortality: an updated systematic analysis. The Lancet. 2011; 378:1139-1165.

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Forouzanfar MH, Foreman KJ, Delossantos AM, Lozano R, Lopez AD, Murray CJL, Naghavi M. Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. The Lancet. 2011; DOI:10.1016/S0140-6736(11)61351-2.

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Naghavi M, Pourmalek F, Shahraz S, Jafari N, Delavar B, Motlagh ME. The burden of injuries in Iranian children in 2005. Population Health Metrics. 2010 Mar 31; 8:5.

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Naghavi M, Shahraz S, Bhalla K, Jafari N, Pourmalek F, Bartels D, Puthenpurakal JA, Motlagh ME. Adverse health outcomes of road traffic injuries in Iran after rapid motorization. Archives of Iranian Medicine. 2009 May; 12(3):284–294.

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The Challenge Ahead: Progress and Setbacks in Breast and Cervical Cancer
September 14, 2011

The IHME policy report The Challenge Ahead: Progress and Setbacks in Breast and Cervical Cancer outlines global, regional, and country trends in cancer cases, deaths, and risks over the past three decades. This is the first global assessment of country-specific trends in breast and cervical cancer for all countries by age and the findings were simultaneously published in The Lancet on September 14, 2011. 

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The Global Burden of Disease: Generating Evidence, Guiding Policy
March 4, 2013

The Global Burden of Disease: Generating Evidence, Guiding Policy provides an overview of the reasons why the Global Burden of Disease (GBD) is an essential tool for evidence-based health policymaking and summarizes the main findings of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010). GBD 2010 is the most comprehensive study of its kind, producing comparative metrics for 291 different causes of premature death and disability across 187 countries, 20 age groups, and both sexes for three time periods: 1990, 2005, and 2010. The study also estimated 67 potentially preventable causes of ill health, or risk factors, such as smoking, high blood pressure, and household air pollution.

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Research Team Leader

Mohsen Naghavi

Associate Professor

Related Research Teams & Projects

Population Health Metrics Research Consortium Mexico Study
Project

Related Content

Research Team
Publications & Presentations

Related Research Teams & Projects

Population Health Metrics Research Consortium Mexico Study
Project

Research Team Leader

Mohsen Naghavi

Associate Professor

Institute for Health Metrics and Evaluation
2301 Fifth Ave., Suite 600, Seattle, WA 98121, USA
Tel: +1.206.897.2800 Fax: +1.206.897.2899
© 2013 University of Washington